Constitutive equations of skeletal muscle based on cross-bridge mechanism
نویسندگان
چکیده
منابع مشابه
The cross-bridge cycle and skeletal muscle fatigue.
The functional correlates of fatigue observed in both animals and humans during exercise include a decline in peak force (P0), maximal velocity, and peak power. Establishing the extent to which these deleterious functional changes result from direct effects on the myofilaments is facilitated through understanding the molecular mechanisms of the cross-bridge cycle. With actin-myosin binding, the...
متن کاملAltered cross-bridge properties in skeletal muscle dystrophies
Force and motion generated by skeletal muscle ultimately depends on the cyclical interaction of actin with myosin. This mechanical process is regulated by intracellular Ca(2+) through the thin filament-associated regulatory proteins i.e.; troponins and tropomyosin. Muscular dystrophies are a group of heterogeneous genetic affections characterized by progressive degeneration and weakness of the ...
متن کاملThe Cross-Bridge of Skeletal Muscle Is Not Synchronized Either by Length or Force Step
Force and length steps, applied to a muscle fiber in the isometric state, are believed to synchronize attached cross-bridges. This alleged synchronization facilitates the interpretation of the experiments. A rapid force step elicits an elastic response of the attached cross-bridges, followed by an isotonic phase. The decay of this second isotonic phase is of the first order. This excludes that ...
متن کاملEvidence for cross-bridge order in contraction of glycerinated skeletal muscle.
The linear dichroism of iodoacetylrhodamine labels attached to the single reactive thiol groups of myosin heads was measured to determine the spatial orientation of myosin cross-bridges in single glycerinated skeletal muscle fibers. We have shown previously that in rigor the chromophoric labels are well ordered and assume an orientation nearly perpendicular to the fiber axis; in the presence of...
متن کاملMuscle cross-bridge chemistry and force.
The recent article by Baker et al. (1999) presents a thermo-dynamic formalism that challenges the commonly held assumption that force production by muscle is localized to individual actin-bound myosin molecules. By assuming that the chemical reaction for the force-producing step is close enough to equilibrium to set ⌬G ϭ 0, the sum of the chemical and mechanical potentials of the products can b...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1985
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(85)83895-9